Fig. 3
From: FTO-dependent m6A regulates muscle fiber remodeling in an NFATC1–YTHDF2 dependent manner
Fto maintains the formation of murine slow-twitch fiber in vivo. A Flow chart of the experiment on C57/BL mice. B Representative immunohistochemical images of MHC1 (green) in the soleus. Scale bar, 100 μm. C Immunofluorescence revealed that the percentage of type I muscle fiber was significantly decreased after treatment with FB23-2. n = 5 in each case; data are represented as mean ± s.d. D Quantitative real-time PCR analysis revealed that FB23-2 treatment decreased the mRNA expression of Myh7 and Myh7b in the soleus. n = 5 in each case; data are represented as mean ± s.d. *P < 0.05