Maternal glycemia in pregnancy is longitudinally associated with blood DNAm variation at the FSD1L gene from birth to 5 years of age

Table 2 CpG sites identified (suggestive P < 10^–5) in linear mixed models (LMM) testing associations between maternal AUC_glu and DNAm measured in cord blood and blood at 5 years of age

CpGs	Chr	Position	Cord blood DNAm levels in β-value Mean ± SD N = 440	Five years blood DNAm levels in β-value Mean ± SD N = 293	Nearest gene	LMM regression estimates
cg00967989	9	108,210,147	0.013 ± 0.002	0.015 ± 0.003	*FSD1L*	β: − 0.0267 P: 2.13 × 10^–08
cg03703356	14	103,989,368	0.073 ± 0.012	0.132 ± 0.016	CKB	β: − 0.0217 P: 4.25 × 10^–07
cg12140144	1	2,984,275	0.017 ± 0.004	0.045 ± 0.008	PRDM16	β: − 0.0251 P: 4.37 × 10^–07
cg07946633	1	2,984,245	0.251 ± 0.034	0.339 ± 0.032	PRDM16	β: − 0.0206 P: 2.24 × 10^–06
cg08694430	9	116,420,234	0.864 ± 0.032	0.838 ± 0.035	RGS3	β: 0.0324 P: 1.33 × 10^–06
cg20153537	3	193,917,170	0.949 ± 0.017	0.944 ± 0.007	HES1	β: − 0.0223 P: 2.70 × 10^–06
cg19978242	10	121,578,846	0.856 ± 0.030	0.886 ± 0.026	INPP5F	β: − 0.0322 P: 4.85 × 10^–06
cg02357751	22	19,710,880	0.014 ± 0.003	0.030 ± 0.015	GP1BB; SEPT5	β: − 0.0368 P: 7.71 × 10^–06
cg23517035	5	133,971,253	0.954 ± 0.010	0.939 ± 0.011	SAR1B	β: 0.0212 p: 8.68 × 10^–06
cg17385945	6	139,095,355	0.010 ± 0.002	0.014 ± 0.003	CCDC28A	β: − 0.0257 p: 9.93 × 10^–06

Model adjusted for maternal age, gravidity, smoking status, child sex, BMI at first trimester of pregnancy and the binary variable for time-point. Significant result after Bonferroni correction with P-value < 6.9 × 10^–8 are in bold
AUC_glu, Area Under the Curve of glucose; Chr, Chromosome; CpG, Cytosine–phosphate–Guanine; DNAm, DNA methylation; SD, Standard deviation

ISSN: 1868-7083