Maternal glycemia in pregnancy is longitudinally associated with blood DNAm variation at the FSD1L gene from birth to 5 years of age

Table 1 Characteristics of Gen3G mother–child pairs during pregnancy, delivery, and child at ~ 5 years

	N	Mean ± SD or median [IQR] or N (%)
Maternal measures – 1st trimester
Age, years	539	28.2 ± 4.2
Gestational age, weeks	539	9.4 [8.1; 11.7]
Primigravid, yes	539	180 (33.4%)
Smoking status, yes	539	49 (9.1%)
BMI, kg/m²	539	23.9 [21.6; 27.9]
Maternal measures – 2nd trimester
Gestational age, weeks	539	26.3 [25.9; 27.1]
GDM, yes	539	50 (9.3%)
Glucose fasting, mmol/L	539	4.2 [3.9; 4.4]
Glucose 1 h post-OGTT, mmol/L	539	7.1 [6.0; 8.2]
Glucose 2 h post-OGTT, mmol/L	539	5.7 [4.8; 6.6]
AUC_glu, mmol/L * h	539	12.0 [10.5; 13.4]
Measures at delivery
Gestational age, weeks	539	39.7 [38.9; 40.4]
Sex, girls	539	252 (46.8%)
Child measures – 5 years
Age, years	293	5.2 [5.1; 5.4]
Sex, girls	293	130 (44.4%)

AUC_glu, Area Under the Curve of glucose; BMI, Body Mass Index; GDM, Gestational Diabetes Mellitus; SD, Standard Deviation

ISSN: 1868-7083