Table 2 Top 20 (of 79) CpGs differentially associated with changes in glycemic measures, RYGB versus IMI
CpG | CHR | Position | Nearest gene | Relation to CpG islands | Change in FPG | Change in HbA1c | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
β (RYGB) | SE (RYGB) | β (IMI) | SE(IMI) | FDR for interaction | β (RYGB) | SE (RYGB) | β (IMI) | SE (IMI) | FDR for interaction | |||||
cg18373318 | 5 | 53813164 | SNX18 | N_Shore |  − 83.3 | 70.0 | 733.8 | 111.6 | 0.001 |  − 2.2 | 2.1 | 23.8 | 3.5 | 0.001 |
cg26878734 | 2 | 176793622 | LNPK | Sea |  − 481.5 | 200.6 | 1244.9 | 218.0 | 0.001 |  − 12.7 | 6.0 | 36.8 | 7.0 | 0.009 |
cg05994094 | 18 | 31020806 | CCDC178 | Island |  − 282.0 | 150.3 | 1474.4 | 253.4 | 0.001 |  − 3.2 | 4.7 | 46.5 | 8.2 | 0.012 |
cg08383526 | 8 | 24297818 | ADAM7 | Sea | 656.5 | 229.9 |  − 1253.1 | 248.6 | 0.007 | 13.8 | 7.4 |  − 37.8 | 8.1 | 0.033 |
cg21191176 | 14 | 23402052 | PRMT5 | S_Shelf | 766.9 | 461.3 |  − 3525.3 | 531.4 | 0.008 | 34.1 | 14.8 |  − 97.2 | 17.2 | 0.012 |
cg18941458 | 1 | 22191585 | HSPG2 | Island | 884.1 | 463.1 |  − 2299.7 | 496.8 | 0.008 | 15.0 | 14.7 |  − 73.1 | 16.3 | 0.041 |
cg03831971 | 4 | 100868132 | DNAJB14 | Island |  − 1852.7 | 511.8 | 3392.9 | 776.4 | 0.008 |  − 40.1 | 16.5 | 104.2 | 25.3 | 0.037 |
cg00658652 | 16 | 71500215 | ZNF23 | S_Shelf | 225.7 | 114.8 |  − 620.4 | 119.2 | 0.008 | 7.5 | 3.8 |  − 16.5 | 4.0 | 0.033 |
cg22964496 | 10 | 126718276 | CTBP2 | S_Shelf | 735.9 | 291.5 |  − 1383.4 | 314.7 | 0.009 | 17.8 | 8.9 |  − 46.7 | 9.8 | 0.017 |
cg08691332 | 12 | 72142653 | – | Sea | 745.5 | 341.7 |  − 1578.2 | 361.5 | 0.01 | 22.4 | 10.9 |  − 43.8 | 11.8 | 0.033 |
cg18144742 | 14 | 107252,125 | – | Sea | 126.7 | 245.8 | 1880.7 | 347.8 | 0.01 | 10.1 | 7.5 | 62.9 | 10.9 | 0.026 |
cg06876872 | 1 | 202110290 | ARL8A | N_Shelf |  − 2234.6 | 496.9 | 1146.7 | 428.5 | 0.011 |  − 35.9 | 14.6 | 57.0 | 13.6 | 0.04 |
cg03863499 | 3 | 191670165 | – | Sea | 210.3 | 350.8 |  − 2691.8 | 435.8 | 0.011 | 19.7 | 11.5 |  − 74.4 | 14.0 | 0.014 |
cg14580737 | 19 | 19301780 | BORCS8-MEF2B | N_Shore | 302.0 | 153.8 |  − 660.0 | 158.8 | 0.012 | 16.4 | 4.8 |  − 13.5 | 5.0 | 0.02 |
cg05310882 | 15 | 83378778 | AP3B2 | Island |  − 239.9 | 853.5 | 8075.1 | 1537.8 | 0.012 | 13.7 | 26.1 | 267.0 | 47.1 | 0.026 |
cg11971662 | 8 | 99499993 | STK3 | Sea | 875.3 | 411.0 |  − 1733.9 | 341.0 | 0.012 | 25.9 | 12.5 |  − 55.7 | 10.4 | 0.02 |
cg01750895 | 17 | 17463041 | PEMT | N_Shelf | 1181.4 | 304.7 |  − 555.4 | 210.3 | 0.013 | 28.6 | 9.0 |  − 20.1 | 6.6 | 0.047 |
cg13288301 | 3 | 52446425 | BAP1 | S_Shore |  − 683.2 | 299.4 | 1678.8 | 433.0 | 0.013 |  − 14.4 | 8.9 | 55.8 | 14.0 | 0.045 |
ch.16.54217905R | 16 | 55660404 | – | Sea | 9355.0 | 2009.4 |  − 1675.1 | 1066.5 | 0.013 | 261.9 | 56.0 |  − 74.2 | 32.2 | 0.017 |
cg13057898 | 1 | 3703894 | LRRC47 | Island | 300.4 | 100.9 |  − 278.1 | 81.4 | 0.013 | 6.5 | 3.1 |  − 10.2 | 2.6 | 0.045 |