Table 3 DMPs significantly associated with ischemic stroke in the discovery (q < 0.05) and replication samples
From: Epigenome-wide association study identifies novel genes associated with ischemic stroke
CpG | Genomic coordinates | Nearest gene | Gene location | Discovery sample (n = 80) | Internal replication (n = 1,771) | External replication (n = 390) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Δ methylation* | P-value | q-value†| Δ methylation* | P-value | q-valuec | Δ methylation* | P-value | q-value‡ | ||||
cg15137954 | Chr11:5618023 | TRIM6 | TSS200 |  − 4.4% | 4.76 × 10−09 | 0.004 |  − 2.1% | 1.28 × 10−41 | 7.65 × 10−41 |  − 4.9% | 0.01 | 0.05 |
cg24891539 | Chr8:55370407 | SOX17 | TSS200 |  − 6.5% | 6.28 × 10−08 | 0.025 | NA | NA | NA | 0.5% | 0.04 | 0.08 |
cg15949239 | Chr15:62988566 | TLN2 | Gene body | 8.5% | 1.93 × 10−07 | 0.039 | 1.9% | 0.053 | 0.053 | 0.2% | 0.62 | 0.62 |
cg11199713 | Chr13:112721773 | SOX1 | TSS200 |  − 3.4% | 1.94 × 10−07 | 0.039 |  − 1.2% | 2.27 × 10−08 | 2.73 × 10−08 | 0.4% | 0.31 | 0.44 |
cg07913294 | Chr1:50489574 | AGBL4 | 5'UTR |  − 2.9% | 2.98 × 10−07 | 0.044 |  − 1.1% | 1.34 × 10−09 | 2.01 × 10−09 | 0.6% | 0.09 | 0.15 |
cg16800165 | Chr14:85996364 | FLRT2 | TSS200 |  − 4.5% | 3.24 × 10−07 | 0.044 |  − 4.4% | 1.25 × 10−09 | 2.01 × 10−09 | 0.2% | 0.50 | 0.59 |
cg11533098 | Chr2:14775132 | FAM84A | 3'UTR |  − 2.6% | 4.09 × 10−07 | 0.048 |  − 0.6% | 1.33 × 10−13 | 4.00 × 10−13 | 0.7% | 0.01 | 0.05 |