Table 2 Significant DMPs associated with ischemic stroke in the discovery sample (P < 1 × 10–5)
From: Epigenome-wide association study identifies novel genes associated with ischemic stroke
CpG | Genomic coordinates | Nearest gene | Gene location | Effect size* | P-value | q-value†|
|---|---|---|---|---|---|---|
cg15137954 | Chr11:5618023 | TRIM6 | TSS200 | − 0.04 | 4.76 × 10–9 | 0.004 |
cg24891539 | Chr8:55370407 | SOX17 | TSS200 | − 0.09 | 6.28 × 10–8 | 0.025 |
cg15949239 | Chr15:62988566 | TLN2 | Body | 0.04 | 1.93 × 10–7 | 0.039 |
cg11199713 | Chr13:112721773 | SOX1 | TSS200 | − 0.05 | 1.94 × 10–7 | 0.039 |
cg07913294 | Chr1:50489574 | AGBL4 | 5'UTR | − 0.04 | 2.98 × 10–7 | 0.044 |
cg16800165 | Chr14:85996364 | FLRT2 | TSS200 | − 0.04 | 3.24 × 10–7 | 0.044 |
cg11533098 | Chr2:14775132 | FAM84A | 3'UTR | − 0.04 | 4.09 × 10–7 | 0.048 |
cg12076203 | chr2:27145848 | DPYSL5 | Body | 0.05 | 6.00 × 10–7 | 0.061 |
cg20931033 | chr1:50489577 | AGBL4 | 1stExon | − 0.05 | 8.60 × 10–7 | 0.070 |
cg17814180 | chr7:86274020 | GRM3 | 1stExon | − 0.03 | 9.49 × 10–7 | 0.070 |
cg16586689 | chr18:46082474 | CTIF | 5'UTR | 0.04 | 1.02 × 10–6 | 0.070 |
cg27646412 | chr10:77501817 | C10orf11 | TSS1500 | 0.06 | 1.31 × 10–6 | 0.070 |
cg15852516 | chr8:17270812 | MTMR7 | 1stExon | − 0.04 | 1.31 × 10–6 | 0.070 |
cg21426003 | chr2:237076811 | GBX2 | TSS200 | − 0.16 | 1.38 × 10–6 | 0.070 |
cg08582701 | chr16:6070005 | A2BP1 | 5'UTR | − 0.05 | 1.40 × 10–6 | 0.070 |
cg14615336 | chr1:50489567 | AGBL4 | 1stExon | − 0.03 | 1.43 × 10–6 | 0.070 |
cg13929328 | chr10:129535898 | FOXI2 | 1stExon | − 0.04 | 1.50 × 10–6 | 0.070 |
cg03135713 | chr13:46961897 | C13orf18 | TSS1500 | 0.06 | 1.54 × 10–6 | 0.070 |
cg23093589 | chr7:20824932 | SP8 | Body | − 0.06 | 2.07 × 10–6 | 0.085 |
cg12789173 | chr11:118084192 | AMICA1 | TSS200 | − 0.09 | 2.08 × 10–6 | 0.085 |
cg06950070 | chr19:6502301 | TUBB4 | 1stExon | 0.05 | 2.33 × 10–6 | 0.091 |
cg05387519 | chr1:50489730 | AGBL4 | TSS200 | − 0.09 | 2.51 × 10–6 | 0.093 |
cg16532100 | chr5:171611704 | STK10 | Body | − 0.03 | 2.83 × 10–6 | 0.095 |
cg01756381 | chr4:11430693 | HS3ST1 | TSS200 | − 0.09 | 2.89 × 10–6 | 0.095 |
cg05362127 | chr3:55515543 | WNT5A | TSS200 | − 0.04 | 2.92 × 10–6 | 0.095 |
cg02294868 | chr8:79579003 | ZC2HC1A | 5'UTR | − 0.02 | 3.29 × 10–6 | 0.100 |
cg18517195 | chr15:71184476 | LRRC49;THAP10 | TSS1500;1stExon | − 0.04 | 3.32 × 10–6 | 0.100 |
cg26026615 | chr12:115130855 |  |  | − 0.06 | 3.67 × 10–6 | 0.107 |
cg00787188 | chr2:213403315 | ERBB4 | 1stExon | − 0.05 | 4.93 × 10–6 | 0.134 |
cg13424673 | chr1:50489744 | AGBL4 | TSS200 | − 0.03 | 4.93 × 10–6 | 0.134 |
cg00903099 | chr7:154862441 | HTR5A | TSS200 | − 0.08 | 5.29 × 10–6 | 0.139 |
cg24637364 | chr1:66259084 | PDE4B | 5'UTR | − 0.12 | 5.74 × 10–6 | 0.146 |
cg10862431 | chr12:63544783 | AVPR1A | TSS200 | − 0.04 | 6.24 × 10–6 | 0.154 |
cg00107187 | chr14:105070998 | TMEM179 | 1stExon | − 0.05 | 6.90 × 10–6 | 0.164 |
cg21590264 | chr5:37834850 | GDNF | 1stExon | − 0.04 | 7.39 × 10–6 | 0.164 |
cg21180443 | chr11:66984956 | KDM2A | TSS200 | − 0.02 | 7.51 × 10–6 | 0.164 |
cg03609960 | chr12:99288805 | ANKS1B | TSS200 | − 0.04 | 7.61 × 10–6 | 0.164 |
cg01546873 | chr5:122523277 | PRDM6 | 3'UTR | 0.05 | 7.78 × 10–6 | 0.164 |
cg08146323 | chr19:57183118 | ZNF835 | 1stExon | − 0.07 | 7.88 × 10–6 | 0.164 |
cg07664198 | chr7:136553882 | CHRM2 | 1stExon | − 0.04 | 8.07 × 10–6 | 0.164 |
cg12842973 | chr20:56650428 |  |  | − 0.06 | 8.54 × 10–6 | 0.166 |
cg00455526 | chr7:28996196 | TRIL | 1stExon | − 0.10 | 8.67 × 10–6 | 0.166 |
cg19524676 | chr5:17218547 | BASP1; LOC285696 | 5'UTR; TSS1500 | − 0.04 | 8.74 × 10–6 | 0.166 |
cg15439862 | chr18:28622593 | DSC3 | 1stExon | − 0.04 | 9.05 × 10–6 | 0.168 |
cg05824976 | chr2:203737195 | ICA1L | TSS1500 | 0.07 | 9.60 × 10–6 | 0.172 |
cg07514158 | chr16:24267526 | CACNG3 | 1stExon | − 0.03 | 9.68 × 10–6 | 0.172 |