Fig. 5
From: Epigenome-wide association study identifies novel genes associated with ischemic stroke
Manhattan (a) and volcano (b) plots displaying the differentially methylated regions (DMRs) associated with ischemic stroke in the discovery sample of 80 Chinese adults (40 cases vs. 40 matched controls). In the Manhattan plot, X-axis indicates the chromosome position; Y-axis indicates the –log10 P-values. The red line denotes the significance threshold at q-value < 0.05. In the volcano plot, blue and red dots highlight significantly hypomethylated and hypermethylated regions, respectively, in cases with respect to controls. Genomic distribution and CpG context (c) of the identified DMRs indicated that these DMRs are mainly located in the first exon, promoter, and CpG Islands