Fig. 2
From: Epigenome-wide association study identifies novel genes associated with ischemic stroke
EWAS in the discovery stage. Manhattan (a) and volcano (b) plots displaying the associations of DNA methylation at 815,017 CpGs with IS in a Chinese sample (40 cases and 40 matched controls). In the Manhattan plot, X-axis indicates the chromosome position; Y-axis indicates the –log10 P-values. The red line denotes the significance threshold at q-value < 0.05. In the volcano plot, blue and red dots highlight significantly hypomethylated and hypermethylated CpG sites, respectively, in cases with respect to controls. c Box plots showing the differences in mean DNA methylation level between cases and controls at the 7 CpG sites significantly associated with IS in the discovery stage