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Table 3 SFARI gene enrichment at multiple p value thresholds

From: Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes

Threshold

Measure

Placenta

Lung

PFC

Heart

Cerebellum

p < 1e−04

Actual

49

2

0

1

5

 

Expected

21.9

0.4

0.5

1.0

1.9

 

OR

2.5

5.7

0.0

1.0

2.9

p < 0.001

Actual

143

5

2

3

19

 

Expected

69.1

1.8

2.6

4.4

9.2

 

OR

2.4

3.0

0.7

0.7

2.2

p < 0.005

Actual

285

13

23

28

56

 

Expected

149.3

8.3

13.2

20.3

34.0

 

OR

2.4

1.6

1.8

1.4

1.8

p < 0.01

Actual

356

27

49

57

102

 

Expected

203.9

17.2

28.7

38.9

65.1

 

OR

2.3

1.6

1.8

1.5

1.7

p < 0.05

Actual

601

198

291

294

402

 

Expected

417.4

116.5

167.9

188.0

257.4

 

OR

2.3

2.0

2.2

1.9

2.1

  1. Statistical analysis performed using a chi-squared test statistic [54]
  2. PFC prefrontal cortex
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Clinical Epigenetics

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