Table 2 Top five DNA methylation loci per tissue associated with prenatal THC exposure

Placenta

cg23018092

6

124,772,737

MEGF10

2.06E−16

4.85E−11

cg27346707

6

124,772,721

MEGF10

7.65E−10

5.99E−05

cg05494467

6

138,890,510

PCDHGA8

5.40E−10

5.99E−05

cg20825437

13

63,151,971

PRKCE

1.45E−09

8.54E−05

cg03721362

6

124,772,671

MEGF10

5.12E−09

0.0002

Cerebellum

cg00617180

4

124,660,978

SUPT3H

4.49E−10

0.000105

cg19948549

5

8,503,869

NSG1

9.65E−10

0.000113

cg17478992

2

151,164,369

SLC12A8

4.69E−07

0.036697

cg13699963

16

69,873,069

SDK2

1.86E−06

0.08718

cg11031701

16

35,959,387

TBX2

1.74E−06

0.08718

Prefrontal Cortex

cg00617180

4

124,660,978

SUPT3H

1.87E−12

4.38E−07

cg01898225

7

78,635,212

LRRC28

4.18E−07

0.049039

cg02616023

1

88,639,226

NOS1AP

2.05E−05

0.999987

cg14964115

9

115,397,494

FAM160B1

2.48E−05

0.999987

cg13915892

13

1,072,439

LMAN2L

3.62E−05

0.999987

Heart

cg22754569

8

59,305,442

NSMAF

4.36E−08

0.010244

cg19504702

6

151,889,356

HAND1

3.34E−07

0.039244

cg00617180

4

124,660,978

SUPT3H

1.10E−06

0.085922

cg03396151

7

13,532,030

MEIS2

6.03E−06

0.353767

cg06933370

7

13,532,249

MEIS2

9.42E−06

0.442549

Lung

cg00617180

4

124,660,978

SUPT3H

7.89E−09

0.001852

cg17760405

4

72,836,058

SIM1

2.11E−05

0.999998

cg10762132

13

15,816,921

SLC20A1

4.46E−05

0.999998

cg23616524

3

156,111,969

UBE2H

6.44E−05

0.999998

cg11126485

14

12,810,784

TMEM138

7.09E−05

0.999998