Fig. 3

DMC genes are enriched for morphogenesis, nucleic acid metabolism, and nervous system development related terms. A The top 10 FDR significant GO terms in the biological processes category are presented for each tissue clustered according to larger parent categories identified using rrvgo. Color indicates the number of tissues enriched for each term and the size of circles indicates − log10 FDR p value across terms. There was no FDR significant enrichment of GO terms in lung tissue. In the placenta, the clusterProfiler R package was used to visualize enriched cellular compartments (B), biological processes (C), and connected genes using the more stringent set of 573 FDR significant DMCs