Fig. 1
![Fig. 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs13148-023-01519-4/MediaObjects/13148_2023_1519_Fig1_HTML.png)
Prenatal THC is associated with differential methylation at individual CpGs in each tissue tested. Volcano plots for each tissue show CpG-specific associations with THC exposure using limma with a factorial design of group and tissue, accounting for within-subject correlation. Each plot depicts the logFC for THC versus CON on the x-axis, − log10(p values) on the y-axis. Percentages indicate relative proportions of nominally significant hypomethylated (blue) and hypermethylated (red) CpGs. The dotted blue line indicates nominal p < 0.05, and the dotted red line indicates CpGs reaching significance after adjusting for multiple comparisons using the Benjamini and Hochberg method to control false discovery rate (FDR)