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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Identifying primary and secondary MLH1 epimutation carriers displaying low-level constitutional MLH1 methylation using droplet digital PCR and genome-wide DNA methylation profiling of colorectal cancers

Fig. 3

DNA methylation patterns across the DMR (chr5: 112,072,926–112,073,958) overlapping the APC gene. A. The DMR (differentially methylated region) associated with the MLH1 epimutation CRCs. B. Bar plot showing mean DNA methylation levels by CRC subgroups. Error bars denote standard deviation. MLH1 epimutation group includes primary MLH1 epimutation and secondary MLH1 epimutation (c.-27C > A) CRCs. MLH1 promoter VUS group includes CRCs from two MLH1: c.-11C > T and one MLH1: c.-[28A > G; 7C > T] carriers

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Clinical Epigenetics

ISSN: 1868-7083

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