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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Identifying primary and secondary MLH1 epimutation carriers displaying low-level constitutional MLH1 methylation using droplet digital PCR and genome-wide DNA methylation profiling of colorectal cancers

Fig. 1

An overview of the study design including descriptions of CRC subgroups and key findings from three main analyses. Analysis 1—genome-wide DNA methylation-based Consensus clustering analysis identified four Consensus Clusters. Analysis 2—applying the Consensus Clustering to six diagnostically challenging CRCs and the classification of three MLH1 methylated EOCRCs and three MLH1 promoter germline VUS carriers into Consensus Cluster 4. Analysis 3—further assessment of DNA methylation and somatic mutational profiles associated with each Consensus Cluster

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Clinical Epigenetics

ISSN: 1868-7083

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