Table 1 The clinicopathological and demographic characteristics of study patients
From: Genome-wide DNA methylation profiling of HPV-negative leukoplakia and gingivobuccal complex cancers
| Â | Training set | Validation set | |
|---|---|---|---|
Leukoplakia (n = 22) | OSCC (n = 74) | OSCC (n = 127) | |
Age at diagnosis | |||
Median age | 43 | 52.5 | 53 |
Range (IQR) | 40–52.25 | 43–62 | 44–61 |
Sex | |||
Male | 20 (90.9%) | 56 (75.7%) | 108 (85%) |
Female | 2 (9.1%) | 18 (24.3%) | 19 (15%) |
Pathological stage | |||
Stage 1 and 2 (Early stage OSCC) | NA | 28 (37.8%) | 44 (34.6%) |
Stage 3 and 4 (Advanced stage OSCC) | NA | 46 (62.2%) | 83 (65.4%) |
Pathological T classification | |||
T1 | NA | 5 (6.8%) | 27 (21.3%) |
T2 | NA | 34 (45.9%) | 42 (33.1%) |
T3 | NA | 3 (4.1%) | 4 (3.1%)) |
T4 | NA | 32 (43.2%) | 54 (42.5%) |
Pathological cervical lymph node involvement | |||
Node negative (N0) | NA | 46 (62.2%) | 75 (59.1%) |
Node positive (N+) | NA | 28 (37.8%) | 52 (40.9%) |
Pathological grade | |||
Hyperplasia | 18 (81.8%) | NA | NA |
Mild dysplasia | 2 (9.1%) | NA | NA |
Moderate dysplasia | 2 (9.1%) | NA | NA |
Well | NA | 7 (9.5%) | 10 (7.9%) |
Moderate | NA | 47 (63.5%) | 97 (76.4%) |
Poor | NA | 20 (27%) | 20 (15.7%) |
Habit profile | |||
Exclusive tobacco users | 7 (31.8%) | 51 (68.9%) | 69 (54.3%) |
Exclusive smoker | 3 (13.6%) | 1 (1.4%) | NA |
Exclusive alcohol drinker | NA | NA | 1 (0.8%) |
Mixed habit** | 8 (36.4%) | 14 (18.9%) | 34 (26.8%) |
No Habit | NA | NA | 3 (2.4%) |
No information | 4 (18.2%) | 8 (10.8%) | 20 (15.7%) |