Marker(s) (cutoff) | Training set | Validation set | ||||||
---|---|---|---|---|---|---|---|---|
Specificity (95% CI) (%) | Sensitivity (95% CI) (%) | Specificity (95% CI) (%) | Sensitivity (95% CI) (%) | |||||
Stage 0-A (n = 76) | Stage B-D (n = 62) | All Stages (n = 138) | Stage 0-A (n = 50) | Stage B-D (n = 48) | All Stages (n = 98) | |||
HepaClear (> 0.481) | 96.2 (91.9–98.6) | 68.4 (56.7–78.6) | 100.0 (94.2–100.0) | 82.6 (75.2–88.5) | 92.0 (84.8–96.5) | 72.0 (57.7–83.4) | 95.8 (85.7–99.5) | 84.7 (76.0–91.2) |
AFP (> 20 ng/mL) | 93.7 (87.9–96.5) | 34.2 (23.7–46.0) | 74.2 (61.5–84.5) | 52.2 (43.5–60.7) | 94.0 (87.4–97.8) | 48.0 (33.7–62.6) | 72.9 (58.2–84.7) | 60.2 (49.8–70.0) |
DCP (> 40 mAU/mL) | 92.0 (86.9–95.5) | 64.7 (54.0–75.2) | 83.9 (72.3–92.0) | 72.9 (64.8–81.0) | 92.0 (84.8–96.5) | 62.0 (46.2–74.6) | 87.5 (74.8–95.3) | 74.5 (63.6–81.9) |