Table 1 Distinguishing performance of 10 hypermethylation markers in tissue validation set
Marker region (Gene) | AUC (95% CI) | Cut-off ΔCt value (Cttar-Ctref) | Sensitivity (%) | Specificity (%) | Youden index |
|---|---|---|---|---|---|
cg14263942(CDKL2) | 0.914 (0.848–0.957) | 4.99 | 85.0 | 100.0 | 0.850 |
cg12701184(USP44) | 0.907 (0.841–0.953) | 5.35 | 80.0 | 100.0 | 0.800 |
cg14570307(ZNF783) | 0.914 (0.849–0.958) | 6.22 | 80.0 | 96.7 | 0.767 |
cg15457058(FOXE3) | 0.879 (0.807–0.932) | 5.38 | 81.7 | 96.7 | 0.783 |
cg07689503(MTHFD2) | 0.915 (0.850–0.958) | 6.03 | 78.3 | 98.3 | 0.767 |
cg20172627(Chr2.25439110) | 0.891 (0.822–0.941) | 6.99 | 78.3 | 96.7 | 0.750 |
cg12840719(CDKN2A) | 0.750 (0.663–0.824) | 3.8 | 61.7 | 100.0 | 0.617 |
cg20288165(LOXL3) | 0.870 (0.796–0.924) | 6.62 | 68.3 | 100.0 | 0.683 |
cg04823311(TRIL) | 0.887 (0.816–0.937) | 3.24 | 73.3 | 100.0 | 0.733 |
cg25214789(C5orf49) | 0.809 (0.728–0.875) | 5.27 | 61.7 | 100.0 | 0.617 |