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Table 1 Blood-buccal cross-tissue correlations of blood-based DNA-methylation measures (n = 21)

From: Associations of socioeconomic disparities with buccal DNA-methylation measures of biological aging

 

Mean differences

Cross-tissue correlation

Mean

SD

95% CI

p

r

PhenoAge Accel

  

 45.03, 56.23

< 0.001 

0.25

  Blood

7.25

8.35

   

  Buccal

57.88

9.56

   

GrimAge Accel

  

12.02, 18.08 

< 0.001

0.48

  Blood

19.04

4.93

   

  Buccal

34.09

4.78

   

DunedinPACE

  

0.39, 0.50

< 0.001

0.31

  Blood

1.07

0.11

   

  Buccal

1.52

0.06

   

Epigenetic-g

  

–

–

0.46

  Blood

0

0.33

   

  Buccal

0

0.23

   
  1. Means, standard deviations (SD), and blood-buccal cross-tissue correlations of DNA-methylation measures of accelerated biological aging (i.e., PhenoAge Acceleration, GrimAge Acceleration), pace of aging (i.e., DunedinPACE), and DNAm-predicted cognitive performance (i.e., Epigenetic-g). Mean comparisons for Epigenetic-g are not possible because beta-methylation values are standardized prior to computation. Based on n = 21 people from Gene Expression Omnibus accession GSE11116 (chronological age mean = 32.24, SD = 16.05)
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Clinical Epigenetics

ISSN: 1868-7083

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