Fig. 1

Validity of DNA methylation deconvolution estimates. Density plots, correlation coefficients, and Bland–Altman plots comparing the estimates from deconvolution to the estimates from a CBC differential. A, B Density plot of estimates for proportions (A), represented as percentages, and absolute counts (B), represented as 10³/µl. The red line represents the distribution of estimates from the differential, and the light blue curve represents the distribution of estimates from using deconvolution. The value for R represents the Pearson correlation coefficient of the estimates for the two methods. C, D Bland–Altman plots to visualize the agreement between the two methods using the estimates for proportions (C) and absolute counts (D). The x-axis is the average of the estimate from the differential and deconvolution. The y-axis is the difference in the estimate from the deconvolution and differential. The horizontal black line is located at the average difference of the estimates, and the two dashed red lines are at the 95% confidence interval for the average difference. Each point is a sample. (ICC = intraclass correlation coefficient)