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Table 1 Characteristics of maternal-infant pairs

From: Impact of intrauterine exposure to maternal diabetes on preterm birth: fetal DNA methylation alteration is an important mediator

 

Maternal diabetes status

 

Characteristics

Non-diabetes

Diabetes

P value

n

828

126

 

Maternal characteristics

 Maternal age (years)

28.0 ± 6.5

30.8 ± 6.3

< 0.001

 Race (non-Hispanic Black)

588 (71.0)

91 (72.2)

0.862

 Education (college and above)

282 (34.1)

38 (30.2)

0.446

 Parity (multiparous)

442 (53.4)

84 (66.7)

0.007

 Smoking

142 (17.1)

23 (18.3)

0.858

 Body mass index (kg/m2)

26.3 ± 5.9

30.8 ± 8.1

< 0.001

 Overweight or obesity at prepregnancy

409 (49.4)

97 (77.0)

< 0.001

 Neonatal characteristics

 Sex (male)

428 (51.7)

76 (60.3)

0.087

 Birthweight (g)

3,134 ± 631

3,059 ± 870

0.241

 Gestational age (wks)

38.8 ± 2.3

37.3 ± 3.4

< 0.001

 Preterm birth

132 (15.9)

41 (32.5)

< 0.001

 Subtype of preterm birth

0.063

  Spontaneous preterm

102(77.3)

25(61.0)

 

  Medically indicated preterm

30(22.7)

16(39.0)

 

 Low birthweight

131 (15.8)

27 (21.4)

0.147

 Fetal growth

< 0.001

  Appropriate for gestational age

664 (80.2)

90 (71.4)

 

  Small for gestational age

90 (10.9)

7 (5.6)

 

  Large for gestational age

74 (8.9)

29 (23.0)

 

 Predicted cord blood cell proportions

  CD8 T cells

0.09 ± 0.03

0.09 ± 0.03

0.589

  CD4 T cells

0.12 ± 0.05

0.12 ± 0.05

0.899

  Natural killer cells

0.06 ± 0.03

0.05 ± 0.03

0.036

  B cells

0.08 ± 0.03

0.09 ± 0.04

0.108

  Monocytes

0.12 ± 0.03

0.11 ± 0.03

0.650

  Granulocytes

0.37 ± 0.14

0.31 ± 0.15

< 0.001

  Nucleated red blood cells

0.18 ± 0.14

0.25 ± 0.18

< 0.001