Fig. 4
From: Distinguishable DNA methylation defines a cardiac-specific epigenetic clock
AVR and GABG DeltaAges. A M&P blood DeltaAge. Differences between AVR (n = 74) and CABG (n = 239) in blood DeltaAges (Overall Chi-squared test p value = 0.002). B M&P cardiac tissue DeltaAge. AVR (n = 68) patients reveal lower values of DeltaAge compared to CABG (n = 224) (Overall Chi-squared test p value = 0.049). C Blood sample size and percentage of DeltaAge distribution according to clinical classification. Differences between AVR(decelerated n = 22; normal = 42; and accelerated n = 10) and CABG AVR (decelerated n = 79; normal = 87; and accelerated n = 73) have been tested utilizing Post Hoc Analysis for Pearson’s Chi-Squared Test. Significant differences were found when comparing normal and accelerated groups (p value 0.006 and 0.011, respectively). D Cardiac tissue distribution has been analyzed utilizing Post Hoc Analysis for Pearson’s Chi-Squared Test. Significant differences were found in AVR versus CABG decelerated groups (p value 0.045). AVR distribution: decelerated n = 27; normal = 25; and accelerated n = 16; CABG distribution: decelerated n = 55; normal = 108; and accelerated n = 61