Fig. 4

Distributions of DNAm age acceleration by genomic features. A Distribution of DNAm age acceleration by DNA-based TP53 mutation status. B Distribution of DNAm age acceleration by tumor mutation burden categorized using tertials (T1 = < 1.0, T2 = 1:0–1.95, T3 = ≥ 1.95); C Distribution of DNAm age acceleration by HRDetect score (dichotomized using 70% as a cutoff); D Distribution of DNAm age acceleration by percent genome with somatic copy number of alterations (SCNAs). Kruskal–Wallis test was used to formally assess median differences by each genomic feature, separately. Pearson correlation test was utilized to test for significance of linear relationship between percent genome with SCNAs and DNAm age acceleration