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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Mediation effects of DNA methylation and hydroxymethylation on birth outcomes after prenatal per- and polyfluoroalkyl substances (PFAS) exposure in the Michigan mother–infant Pairs cohort

Fig. 3

Number and direction of significant associations between PFAS and 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) after stratification of loci with a significant PFAS: type of methylation interaction (n = 70). A shows all sites with a significant association between each PFAS and 5-mC (q < 0.05) and B shows the 5-hmC sites (q < 0.05). Counts above the horizontal line at zero represent the number of sites that were positively associated with each PFAS, and counts below the horizontal line represent the number of sites that were negatively associated with each PFAS. Abbreviations: MeFOSAA: 2-(N-methyl-perfluorooctane sulfonamido) acetic acid; PFAS: per-/polyfluoroalkyl substances; PFHxS: perfluorohexanesulphonic acid; PFDA: perfluorodecanoic acid; PFNA: perfluorononanoic acid; PFOS: perfluorooctanesulfonic acid; PFUnDA: perfluoroundecanoic acid

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Clinical Epigenetics

ISSN: 1868-7083

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