Distinct DNA methylation signatures associated with blood lipids as exposures or outcomes among survivors of childhood cancer: a report from the St. Jude lifetime cohort

Dong, Qian; Chen, Cheng; Song, Nan; Qin, Na; Plonski, Noel-Marie; Finch, Emily R.; Shelton, Kyla; Easton, John; Mulder, Heather; Plyer, Emily; Neale, Geoffrey; Walker, Emily; Li, Qian; Huang, I-Chan; Zhang, Jinghui; Wang, Hui; Hudson, Melissa M.; Robison, Leslie L.; Ness, Kirsten K.; Wang, Zhaoming

doi:10.1186/s13148-023-01447-3

Table 3 Additional significant CpGs identified in meta-analysis of blood lipids EWAS among survivors of European and African ancestry (P < 9 × 10⁻⁸)

From: Distinct DNA methylation signatures associated with blood lipids as exposures or outcomes among survivors of childhood cancer: a report from the St. Jude lifetime cohort

EWAS	Lipid	CpG	chr_hg38	Start_hg38	Nearby genes	Population	Effect	SE	P	Directions (EA/AA)	I²	P_het
Exposure	HDL	cg27324117	chr4	153793134	NA	EA	− 0.0025	0.0005	2.11E−07
						AA	− 0.0016	0.0012	0.20
						Meta	− 0.0024	0.0004	8.71E−08	−/−	0	0.4765
		cg02443467	chr10	47191407	NA	EA	− 0.0022	0.0004	1.17E−07
						AA	− 0.0016	0.0010	0.09
						Meta	− 0.0021	0.0004	2.30E−08	−/−	0	0.5916
		cg07373304	chr16	998982	RP11-161M6.3	EA	− 0.0021	0.0004	2.26E−07
						AA	− 0.0044	0.0017	0.01
						Meta	− 0.0023	0.0004	1.41E−08	−/−	36	0.2115
	TG	cg01082498	chr11	68840756	CPT1A	EA	− 0.0006	0.0001	1.24E−07
						AA	− 0.0005	0.0007	0.48
						Meta	− 0.0006	0.0001	7.23E−08	−/−	0	0.8322
		cg06004232	chr16	11293335	RMI2	EA	0.0003	6.09E−05	1.20E−07
						AA	0.0007	0.0003	0.04
						Meta	0.0003	0.0001	1.79E−08	+/+	5.7	0.3032
		cg11686214	chr19	58573616	CENPBD1P1;MZF1;MZF1-AS1	EA	0.0006	0.0001	1.45E−07
						AA	0.0006	0.0006	0.24
						Meta	0.0006	0.0001	5.20E−08	+/+	0	0.929
Outcome	TG	cg23550429	chr2	30797935	CAPN13	EA	− 40.3640	20.2715	0.05
						AA	− 14.9963	2.8360	3.37E−07
						Meta	− 15.4833	2.8087	3.54E−08	−/−	34.9	0.2152
		cg03260858	chr3	49103337	QARS	EA	20.1158	13.6051	0.14
						AA	38.5596	6.9392	9.14E−08
						Meta	34.7521	6.1816	1.89E−08	+/+	31.4	0.2272
		cg20601481	chr11	67288314	ANKRD13D	EA	− 27.9673	10.8875	0.01
						AA	− 37.6708	7.6983	2.10E−06
						Meta	− 34.4364	6.2857	4.29E−08	−/−	0	0.4668
		cg19590858	chr14	34540645	EAPP;RP11-671J11.5	EA	− 31.9752	9.1836	5.17E−04
						AA	− 27.2994	6.6324	5.73E−05
						Meta	− 28.9022	5.3768	7.64E−08	−/−	0	0.6798
		cg20433103	chr17	63941062	SCN4A	EA	43.8451	13.1675	8.98E−04
						AA	36.7039	8.0731	9.67E−06
						Meta	38.6549	6.8825	1.95E−08	+/+	0	0.6438
		cg07439166	chr19	35902502	AD000864.6;HCST;NFKBID	EA	− 51.5564	15.2318	7.37E−04
						AA	− 34.0310	7.4137	8.01E−06
						Meta	− 37.3876	6.666	2.04E−08	−/−	6.6	0.3009

chr_hg38 chromosome in GRCh38/hg38, Start_hg38 CpG start position in GRCh38/hg38, HDL high-density lipoprotein, LDL low-density lipoprotein, TG triglycerides, TC total cholesterol, EA survivors of European ancestry, AA survivors of African ancestry

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ISSN: 1868-7083

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