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Table 1 Characteristics of mother-newborn pairs by newborn sex in the BBC and IOWBC

From: Sex differences in the intergenerational link between maternal and neonatal whole blood DNA methylation: a genome-wide analysis in 2 birth cohorts

 

Mother-newborn pairs from the BBC

Pre-pregnancy mother-newborn pairs from the IOWBC

Early-pregnancy mother-newborn pairs from the IOWBC

Female

Male

P

Female

Male

P

Female

Male

P

Total N

180

216

 

18

30

 

47

46

 

Maternal age at delivery, yr*

27.5 (15.3—46.2)

27.6 (16.5—46.8)

0.91

23.0 (20.3—26.6)

23.4 (21.3—27.3)

0.91

23.3 (21.2—29.7)

23.3 (21.2—33.3)

0.93

Type of delivery

  

0.23

  

0.78

  

0.97

Spontaneous vaginal

131 (72.8%)

144 (66.7%)

 

15 (83.3%)

24 (80.0%)

 

40 (85.1%)

39 (84.8%)

 

C-section

49 (27.2%)

72 (33.3%)

 

3 (16.7%)

6 (20.0%)

 

7 (14.9%)

7 (15.2%)

 

Preterm delivery

  

0.01

  

0.88

  

0.57

No

160 (88.9%)

171 (79.2%)

 

17 (94.4%)

28 (93.3%)

 

45 (95.7%)

45 (97.8%)

 

Yes

20 (11.1%)

45 (20.8%)

 

1 (5.6%)

2 (6.7%)

 

2 (4.3%)

1 (2.2%)

 

Maternal smoking during pregnancy

0.87

  

0.95

  

0.57

  

No

159 (88.3%)

193 (89.4%)

 

11 (61.1%)

18 (60.0%)

 

29 (61.7%)

31 (67.39%)

 

Yes

21 (11.7%)

23 (10.6%)

 

7 (38.9%)

12 (40.0%)

 

18 (38.3%)

15 (32.6%)

 

Maternal race/ethnicity

  

0.57

  

–

  

–

Black

115 (63.9%)

145 (67.1%)

 

–

–

 

–

–

 

Non-Black

65 (36.1%)

71 (32.9%)

 

–

–

 

–

–

 

Birth order

  

0.23

  

0.65

  

0.44

First birth

75 (41.7%)

108 (50.0%)

 

12 (66.7%)

18 (60.0%)

 

23 (48.9%)

25 (54.4%)

 

Second birth

52 (28.9%)

50 (23.1%)

 

4 (22.2%)

8 (26.7%)

 

11 (36.2%)

13 (28.3%)

 

Third birth and later

53 (29.4%)

58 (26.9%)

 

2 (11.1%)

4 (13.3%)

 

7 (14.9%)

8 (17.4%)

 
  1. *Median (range) of maternal age at delivery
  2. A p-value < 0.05 is defined as statistical significant