Parity is associated with long-term differences in DNA methylation at genes related to neural plasticity in multiple sclerosis

Table 4 Differentially methylated regions (DMRs)

Chr	Region (bp)	Width (bp)	Gene	Feature	CpGs	∆_max	∆_mean
17	76128906–76130139	1233	TMC8	Body/TSS1500	cg16301617 cg16935597 cg14055168 cg04945945 cg22833809 cg01791634 cg18437480	0.017	0.013
19	52390810–52391789	979	ZNF577	Body/TSS200/TSS1500	cg06878361 cg03562414 cg10635122 cg24794228 cg10783469 cg16731240 cg23010048 cg11269599 cg22331349 cg09547119 cg12227172 cg22472290 cg13393830 cg25361850	− 0.033	− 0.023

Chr, chromosome; bp, base pair; DMP, differentially methylated position; CpG, cytosine-phosphate-guanine; max, maximum; TMC8, transmembrane channel like 8; ZNF577, zinc finger protein 577; and TSS1500, transcript start site (up to 1500 bp 5′ of 5′UTR) promoter region

ISSN: 1868-7083