Long-term impact of paediatric critical illness on the difference between epigenetic and chronological age in relation to physical growth

Table 3 DNAm age-deviation in former PICU-patients as compared with healthy children

Analyses	Percentage of significant bootstrap replicates	Median p-value
Without interaction	51	0.04936
Interaction with age at PICU admission	83	0.00107
Interaction with race	28	0.16330
Interaction with origin	13	0.40436
Interaction with gender	11	0.41110
Interaction with centre	6	0.45385
Interaction with syndrome	2	0.63393

Summary of the bootstrapped multivariable linear regression models adjusted for baseline risk factors. The first model assessed whether a significant DNAm age-deviation was present in former PICU-patients as compared with healthy children, adjusted for baseline risk factors (first row). Next, for each baseline risk factor separately, an interaction term with patient-control status was additionally brought into the model (other rows). For each model, the percentage of significant bootstrap replicates is shown, as well as the median p-value of all bootstrap replicates

ISSN: 1868-7083