Skip to main content

Table 2 Essential differentially methylated genes and the genes in the epigenetic function modules

From: Genetic, DNA methylation, and immune profile discrepancies between early-stage single primary lung cancer and synchronous multiple primary lung cancer

Entrez ID

Symbol

Full name

Function

Size

Genes in the module

148

ADRA1A

Adrenoceptor alpha 1A

Immune response

18

ADRA1A, NOS1, ADRA1D, CXCR1, CXCR2, CXCL3, CXCL6, CXCL5, CXCL2, CXCL1, CXCL8, MYO5B, RAB11B, RAB25, RASD1, DPP4, SNTG1, VAC14

1906

EDN1

Endothelin 1

Tumorigenesis

29

EDN1, EDNRB, KEL, EDNRA, COL1A2, CYSLTR2, MME, COL3A1, ECE1, ADM, MMP1, EDN2, EDN3, VIP, ADCYAP1, ADCYAP1R1, VIPR2, VIPR1, COL5A3, DDR2, COL11A2, LUM, NPPA, NPPC, NPR3, NPPB, NPR2, GAST, RAMP1

3579

CXCR2

C-X-C motif chemokine receptor 2

Immune response

20

CXCR2, RGS12, AP2A1, CXCL8, CXCR1, CXCL2, ADRA1A, CXCL1, CXCL5, MYO5B, CXCL3, CXCL6, NPY2R, RAB11B, AP2S1, RAB25, ADRA1D, DPP4, SNTG1, NAGPA