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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Genetic, DNA methylation, and immune profile discrepancies between early-stage single primary lung cancer and synchronous multiple primary lung cancer

Fig. 4

DNA methylation discrepancies between sMPLC and SPLC. A Heatmap generated from clustering analysis illustrated the DMP between sMPLC and SPLC. B and C The PPI network analysis identified CXCR2, EDN1, and ADRA1A as essential differentially methylated genes. The epigenetic function modules were established to illustrate the interactions of the related genes. The CXCR2 and ADRA1A closely interacted and were shown in a same module. D and E Aberrant DNA methylation at the TSS region was significantly related to the abnormal expression of immune-related genes. In sMPLC, the r = − 0.541, p = 0.002; in SPLC, the r = − 0.773, p < 0.0001

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Clinical Epigenetics

ISSN: 1868-7083

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