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Table 4 Placental DNA differentially methylated regions (DMRs) in LGA vs. OGA newborns identified in both comb-p and DMRcate package analyses

From: Genome-wide placental DNA methylations in fetal overgrowth and associations with leptin, adiponectin and fetal growth factors

DMR

CpGs of

the DMR

Direction of association

Nearby

gene

Gene

group

Chr21:48,078,809–48,079,700

cg01123035, cg22256816

 + / + 

PRMT2

Body

chr11:117,166,784–117,167,825

cg22974118, cg03026698,

cg27313579, cg01814586,

cg07189750

 ± / + / ± 

BACE1

TSS1500;Body

Chr2:202,286,912–202,287,373

cg01561344, cg16375762

 − / + 

TRAK2

5'UTR

  1. LGA, large-for-gestational-age (birth weight > 90th percentile); OGA = optimal-for-gestational-age (birth weight 25th–75th percentiles)
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Clinical Epigenetics

ISSN: 1868-7083

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