Genome-wide placental DNA methylations in fetal overgrowth and associations with leptin, adiponectin and fetal growth factors

Table 2 Top 25 hypermethylated sites in placental DNAs in LGA versus OGA newborns

CpG	Gene	Gene Group	Adjusted P	Avg_ LGA	Avg_ Con	Delta Beta
cg22733133	EN2	Body	0.045	0.53	0.34	0.19
cg09473315	LOC283999	Body	0.038	0.32	0.14	0.18
cg20159490			0.040	0.70	0.52	0.18
cg27655158			0.045	0.34	0.17	0.17
cg20065768			0.036	0.66	0.50	0.16
cg11700298	CADM2	5′UTR; Body	0.036	0.76	0.60	0.16
cg17470674			0.004	0.82	0.66	0.16
cg01359081	ADGB	Body	0.014	0.47	0.31	0.16
cg17722823	KRTAP13-4	TSS200	0.045	0.51	0.36	0.15
cg09562045	CRMP1	Body;TSS200	0.033	0.28	0.13	0.15
cg27295595			0.044	0.60	0.45	0.15
cg06039355	GFRA1	5′UTR;TSS1500;	0.026	0.44	0.30	0.14
cg06292076			0.038	0.44	0.30	0.14
cg23524195	GFRA1	TSS1500	0.039	0.30	0.17	0.13
cg15134685	NRXN1	1stExon;5'UTR;Body	0.043	0.38	0.25	0.13
cg08045176			0.038	0.61	0.48	0.13
cg17650274	VSX1	TSS1500	0.018	0.54	0.41	0.13
cg20926288	PPFIA2	5′UTR	0.032	0.82	0.69	0.13
cg13565656	PLXNC1	1stExon	0.049	0.28	0.15	0.13
cg22916722			0.015	0.23	0.10	0.13
cg14645317	DNAJB5	TSS1500	0.045	0.42	0.29	0.13
cg01735366			0.030	0.79	0.66	0.13
cg14480194			0.006	0.38	0.26	0.12
cg25623522	DAOA	TSS1500;	0.031	0.71	0.58	0.12
cg00657674	ZPLD1	3′UTR	0.027	0.62	0.50	0.12

LGA, large-for-gestational-age (birth weight > 90th percentile); OGA = optimal-for-gestational-age (birth weight 25th–75th percentiles)
The gene name in bold, the CpG site was selected in the pyrosequencing validation study

ISSN: 1868-7083