Table 3 Mediation analysis of metabolic parameters on the association between dietary glycaemic parameters and methylation/hydroxymethylation measures

Glucose

− 0.017 [− 0.119; 0.020],

0.37

− 0.007 [− 0.082; 0.020],

0.52

0.060 [− 0.014; 0.330],

0.10

C-peptide

0.002 [− 0.030; 0.050],

0.74

0.010 [− 0.039; 0.080],

0.56

1.69e−03 [− 4.97e−02; 0.06],

0.80

Insulin

− 3.32e−04 [− 3.87e−02; 0.03],

0.94

0.002 [− 0.026; 0.05],

0.77

9.30e−04 [− 4.99e−02; 0.07],

0.86

Total cholesterol

0.0002 [− 0.0308; 0.03],

0.93

7.02e−05 [− 2.66e−02; 0.03],

0.97

− 8.22e−03 [− 1.53e−01; 0.07],

0.65

LDL

0.002 [− 0.027; 0.06],

0.75

− 0.006 [− 0.076; 0.03],

0.68

− 1.06e−04 [− 3.95e−02; 0.04],

0.98

HDL

4.46e−04 [− 3.29e−02; 0.04],

0.90

3.91e−05 [− 2.63e−02; 0.03],

0.98

1.41e−03 [− 9.13e−02; 0.12],

0.93

CRP (log-scale)

5.69e−04 [− 3.45e−02; 0.04],

0.88

9.63e−04 [− 3.22e−02; 0.04],

0.83

− 2.48e−04 [− 5.30e−02; 0.04],

0.93