DNA methylation in human gastric epithelial cells defines regional identity without restricting lineage plasticity

Table 2 Hypomethylated promoter regions in IM

Gene	Hypomethylated CpGs/promoter region	Total CpGs/promoter	logFC	p Value	FDR	Detected in	5Aza logFC
TRIM15	9	25	2.11	0.0000	0.0000	Ex vivo and in vivo	1.66
ASCL2	6	45	1.27	0.0000	0.0003	Ex vivo and in vivo	0.79
HOXA2	15	28	1.24	0.0000	0.0053	Ex vivo
HMGA1	3	17	1.09	0.0000	0.0000	Ex vivo
TMEM154	3	7	0.92	0.0040	0.1257	Ex vivo
KRT23	2	6	0.91	0.0045	0.1351	Ex vivo	4.25
FUT6	4	8	0.90	0.0033	0.1117	Ex vivo and in vivo	0.99
GAL3ST2	2	6	0.88	0.0006	0.0315	Ex vivo and in vivo
GJC2	2	13	0.67	0.0370	0.4529	Ex vivo	2.89
SYNE1	2	21	0.66	0.0266	0.3812	Ex vivo	1.48
C8orf74	2	6	0.64	0.0469	0.5108	Ex vivo
HOXA4	10	24	0.62	0.0262	0.3786	Ex vivo
DCHS2	2	15	− 0.64	0.0093	0.2145	Ex vivo

Shown are the 13 genes with hypomethylated promoter regions in IM that also show altered gene expression. The in vivo samples represent antral samples with a high methylation cluster. 5 aza = 5-aza-2′-deoxycytidine; logFC = log2 fold change; FDR = false discovery rate

ISSN: 1868-7083