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Table 1 Clinical characteristics of the study population before and after bariatric surgery

From: Bariatric surgery-induced weight loss and associated genome-wide DNA-methylation alterations in obese individuals

Discovery

T0 (Baseline)

T6

(6 months)

T12 (12 months)

p-Value

T0 vs. T6

p-Value

T6 vs. T12

p-Value

T0 vs. T12

N subjects

22

22

20

   

Male/Female (n)

2/20

2/20

2/18

   

Age (years)

47.61 (41.93–55.75)

48.21 (42.53–56.35)

48.81 (43.13–56.95)

   

Height

163.5 ( 157.8–167.3)

163 (158–168)

161 (158–167.3)

   

Weight

125.3 (100.8–138.5)

89.05 (80.45–99.43)

80.15 (69.15–94.75)

 < 0.001

 < 0.001

 < 0.001

BMI (kg/m2)

43.42 (39.64–50.06)

33.47 (29.88–36.04)

30.73 (26.53–32.50)

 < 0.001

 < 0.001

 < 0.001

Waist circumference (cm)

122 (115–130)

101 (93.75–110.8)

95 (85.25–106.8)

 < 0.001

 < 0.001

 < 0.001

Hip circumference (cm)

142 (128–150)

123.3 (111.5–127.3)

115 (103.5–124.5)

 < 0.001

 < 0.001

0.0057

HOMA-IR*

4.32 (3.15–7.81)

1.59 (1.16–2.57)

1.54 (1.03–2.02)

 < 0.001

0.3118

 < 0.001

HbA1c (mmol/mol)

39 (36–44)

33.5 (31.75–35.5)

34.5 (32–36.75)

 < 0.001

0.6154

 < 0.001

Hypertension (n)

6 (27.27%)

3 (13.63%)

3 (15%)

   

Dyslipidemia (n)

15 (68.18%)

10 (45.45%)

7 (35%)

   

Impaired fasting

glucose (n)

6 (27.27%)

1 (4.54%)

1 (5%)

   
  1. Continuous variables are expressed as median (IQ range) and discrete variables are reported as the number of subjects (%). Wilcoxon signed-rank test was used to analyze intergroup differences before surgery and 6 and 12 months after bariatric surgery
  2. *HOMA-IR = Homeostatic Model Assessment for Insulin Resistance
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Clinical Epigenetics

ISSN: 1868-7083

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