Fig. 1
Differentially methylated positions (DMPs) between mild and severe groups in whole-blood. A Of 1472 DMPs, 839 (57%) were hypomethylated (shown in blue) and 633 (43%) were hypermethylated (shown in red) in the severe group. 22 DMPs had a Δmeth above 5% (indicated by the dashed line). B Methylation quantitative trait loci (mQTLs) for each major DMP (Δmeth > 5%). Methylation beta value for each DMP is plotted by genotype at the most significant mQTL based on p-value. The plotted CpG-SNV pairs are: cg10070864-15:57665782 (p = 7.25 × 10–15), cg07199764-1:5348270 (p = 7.50 × 10–13), cg07499182-13:33824770 (p = 4.76 × 10–06), cg17015133-1:155106697 (p = 4.17 × 10–02), cg14433904-8:78519337 (p = 4.33 × 10–12), cg24833027-8:1902112 (p = 1.43 × 10–10), cg00401101-5:16508674 (p = 1.01 × 10–17), cg08434374-11:44471561 (p = 5.46 × 10–05), cg03453431-7:157226016 (p = 7.05 × 10–21), cg16958467-15:57655776 (p = 8.69 × 10–29), cg00541777-2:3652616 (p = 5.22 × 10–28), cg01156747-7:120429 (p = 9.31 × 10–36), cg17322118-1:85744472 (p = 2.14E-12), cg12257246-8:25240100 (p = 4.73E-17), cg00267320-10:111537595 (p = 3.73E-02), cg00570954-12:4281245 (p = 2.50 × 10–26), cg13883027-2:62887884 (p = 3.11 × 10–38), cg25261547-19:49364511 (p = 7.81 × 10–03), cg21728101-7:1976457 (p = 3.48 × 10–04), cg14859874-1:154239283 (p = 1.13 × 10–30), cg19192981-15:57667027 (p = 2.28 × 10–06). The list of mQTLs and p-values for each major DMP are listed in Additional file 2: Table S12. Δmeth delta beta, SNV single-nucleotide variant