Table 1 Correlation between TMB and clinical phenotype for 59-Brazilian patients with nMTCL
Characteristic | Low-TMB (N, %) (48/59–81.3%) | High-TMB (N, %) (11/59–18.7%) | p value |
|---|---|---|---|
Male gender | 25 (52.1%) | 09 (81.8%) | p = 0.06 |
IPI ≥ 3 points | 26 (54.2%) | 07 (63.6%) | p = 0.56 |
PIT ≥ 3 points | 23 (47.9%) | 07 (63.6%) | p = 0.34 |
ECOG ≥ 2 | 25 (52.1%) | 08 (72.8%) | p = 0.21 |
Bulky disease ≥ 7 cm | 26 (54.2%) | 10 (90.9%) | p = 0.01 |
B-symptoms | 39 (81.3%) | 10 (90.9%) | p = 0.41 |
BM infiltration | 05 (10.4%) | 02 (18.2%) | p = 0.78 |
≥ 2 extra nodal sites | 13 (27.1%) | 03 (27.3%) | p = 0.87 |
Clinical stage III/IV | 45 (93.8%) | 11 (100%) | p = 0.75 |
ORR | 29 (60.4%) | 04 (36.4%) | p = 0.08 |
Mortality | 23 (47.9%) | 09 (81.8%) | p = 0.04 |