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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Identification of hepatocellular carcinoma subtypes based on PcG-related genes and biological relevance with cancer cells

Fig. 5

Overexpression of CBX2 contributes to aberrant epigenetic landscape of HCC cells. A The mRNA expression of PcG genes of HCC patients in different epigenetic subgroups. **p < 0.01; ****p < 0.001. B The Kaplan–Meier curve based on survival analysis of HCC patients expressing high or low level of CBX2. C The mRNA level of CBX2 in tumor and adjacent tissue of HCC patients. The relative mRNA level was normalized by β-actin (ACTB). D The IHC assay of CBX2, H3K27me1 and H2AK119ub in high and low CBX2 expression HCC groups. The black bars represent 200 μm. E The correlation analysis of CBX2 expression with H3K27me3 or H2AK119ub expression. The Pearson coefficients were calculated. F The immunoblot of H3K27me1 and H2AK119ub in CBX2 knockdown HCC cells. G The immunoblot of H3K27me3 and H2AK119ub in CBX2 overexpression HCC cells

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Clinical Epigenetics

ISSN: 1868-7083

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