Table 3 Significantly over-represented gene sets (FDR < 0.05) among the 303 genes annotated to CpGs associated with fasting glucose and HOMA-IR
From: Epigenetics of type 2 diabetes and diabetes-related outcomes in the Strong Heart Study
Database | ID | Description | q val | Gene IDs |
|---|---|---|---|---|
GO BP | GO:0071897 | DNA biosynthetic process | 0.012 | HNRNPU, TELO2, DCP2, PTGES3, NEK7, ARRB2, WRN, RPA1, CCT2, TRIM25, SH2B1, GAR1, PARP10 |
GO BP | GO:0007004 | Telomere maintenance via telomerase | 0.012 | HNRNPU, TELO2, DCP2, PTGES3, NEK7, RPA1, CCT2, GAR1 |
GO BP | GO:0006278 | RNA-dependent DNA biosynthetic process | 0.016 | HNRNPU, TELO2, DCP2, PTGES3, NEK7, RPA1, CCT2, GAR1 |
GO BP | GO:0010833 | Telomere maintenance via telomere lengthening | 0.020 | HNRNPU, TELO2, DCP2, PTGES3, NEK7, RPA1, CCT2, GAR1 |
GO BP | GO:0016236 | Macroautophagy | 0.039 | WDR81, PACS2, MLST8, TSC2, SNF8, RB1CC1, YOD1, FEZ2, NBR1, UVRAG, EI24, ATP6V1H, VPS4A, CLEC16A, ATG13 |
GO BP | GO:0043161 | Proteasome-mediated ubiquitin-dependent protein catabolic process | 0.039 | ANAPC11, MAPK9, ARRB2, CDC20B, PSMF1, TRIM9, FBXL19, CUL2, USP19, TRIM25, ANAPC2, TMEM129, YOD1, DNAJB12, WWP2, ARIH2, CBFA2T3, NEDD4L |
GO MF | GO:0003712 | Transcription coregulator activity | 0.011 | JUP, HNRNPU, TRIM27, PSMC3IP, HIPK2, TRIM52, LIMD1, FHL2, HDAC1, FBXL19, CCAR1, CBX4, TRIM25, TCF25, RERE, DPF1, TP53BP1, MED24, LPXN, PARP10, CBFA2T3 |
GO MF | GO:0051019 | Mitogen-activated protein kinase binding | 0.024 | MAPK7, ARRB2, DUSP4, CDK5RAP3, NBR1 |
GO MF | GO:0003714 | Transcription corepressor activity | 0.024 | HNRNPU, HIPK2, LIMD1, FHL2, HDAC1, CCAR1, CBX4, TCF25, RERE, PARP10, CBFA2T3 |
GO CC | GO:0005635 | Nuclear envelope | 0.001 | TRIM27, TNPO3, KPNA4, SLC22A18, WTAP, CHMP7, ALG14, CCAR1, P2RX5, CCND2, RB1CC1, EI24, DNAJB12, OSBPL6, NRXN1, NUP214, SYNE1, SREBF1, CASC3, SMOX, POM121L12 |
GO CC | GO:0031965 | Nuclear membrane | 0.019 | TRIM27, KPNA4, WTAP, ALG14, P2RX5, CCND2, RB1CC1, EI24, DNAJB12, OSBPL6, NRXN1, SYNE1, CASC3, SMOX |
GO CC | GO:0005770 | Late endosome | 0.023 | WDR81, CHMP7, CTNS, SNF8, CD63, LAMP3, NBR1, UVRAG, TMEM59, VPS4A, ARL8B, CLEC16A, NEDD4L |
GO CC | GO:0000152 | Nuclear ubiquitin ligase complex | 0.030 | ANAPC11, CDC20B, CBX4, ANAPC2, PCGF1 |
GO CC | GO:0030176 | Integral component of endoplasmic reticulum membrane | 0.030 | TECR, FICD, SEC61A1, PIGK, PIGT, CANX, SGMS2, ELOVL6, DNAJB12 |
GO CC | GO:0005774 | Vacuolar membrane | 0.030 | WDR81, VASN, SLC44A2, WDR59, DAGLB, CTNS, SPAG9, CD63, RB1CC1, LAMP3, UVRAG, TMEM59, ATP6V1H, VPS4A, ARL8B, CLEC16A |
GO CC | GO:0031932 | TORC2 complex | 0.030 | TELO2, MLST8, PRR5 |
GO CC | GO:0031227 | Intrinsic component of endoplasmic reticulum membrane | 0.030 | TECR, FICD, SEC61A1, PIGK, PIGT, CANX, SGMS2, ELOVL6, DNAJB12 |
GO CC | GO:1990023 | Mitotic spindle midzone | 0.039 | HNRNPU, RCC2, NUMA1 |
GO CC | GO:0038201 | TOR complex | 0.043 | TELO2, MLST8, PRR5 |
Hallmark | TGF Beta Signaling | TGF Beta Signaling | 0.024 | HIPK2, SPTBN1, THBS1, HDAC1, FURIN, FNTA |