Table 2 CpGs prospectively associated with incident diabetes in a Cox proportional hazards model at a nominal p value < 0.01
From: Epigenetics of type 2 diabetes and diabetes-related outcomes in the Strong Heart Study
CpG | Chr | Gene | Function | Adjusted for covariatesa | Adjusted for covariates + fasting glucose | Adjusted for covariates + HOMA-IR | |||
|---|---|---|---|---|---|---|---|---|---|
HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | ||||
cg11024682 | 17 | SREBF1 | Obesity, type 2 diabetes and insulin sensitivity | 1.92 (1.35, 2.74) | 0.0003 | 1.66 (1.16, 2.37) | 0.005 | 1.66 (1.17, 2.35) | 0.005 |
cg07750706 | 6 | PLAGL1 | Transient neonatal diabetes mellitus | 0.63 (0.47, 0.83) | 0.0009 | 0.67 (0.51, 0.89) | 0.005 | 0.66 (0.5, 0.87) | 0.003 |
cg23053438 | 3 | HEG1 | Regulator of heart and vessel formation | 0.64 (0.49, 0.83) | 0.001 | 0.66 (0.51, 0.87) | 0.003 | 0.67 (0.51, 0.88) | 0.004 |
cg01885480 | 15 | OAZ2 | Polyamine biosynthesis, type 2 diabetes | 0.64 (0.49, 0.84) | 0.001 | 0.67 (0.51, 0.88) | 0.003 | 0.69 (0.53, 0.9) | 0.007 |
cg06500161 | 21 | ABCG1 | Cholesterol and phospholipids transport | 1.54 (1.16, 2.03) | 0.003 | 1.38 (1.03, 1.84) | 0.03 | 1.27 (0.95, 1.69) | 0.11 |
cg22710955 | 7 | POP7 | Ribosome biogenesis | 0.66 (0.5, 0.87) | 0.003 | 0.70 (0.53, 0.92) | 0.01 | 0.69 (0.52, 0.91) | 0.009 |
cg20463945 | 6 | C6orf136 | Uncharacterized function | 0.70 (0.54, 0.9) | 0.006 | 0.75 (0.58, 0.97) | 0.03 | 0.69 (0.54, 0.9) | 0.006 |
cg15269194 | 7 | FAM3C | Type 2 diabetes and non-alcoholic fatty liver disease | 0.70 (0.54, 0.9) | 0.006 | 0.75 (0.59, 0.97) | 0.03 | 0.69 (0.53, 0.9) | 0.006 |
cg27089547 | 16 | ZNF747 | Uncharacterized function | 0.69 (0.52, 0.9) | 0.006 | 0.72 (0.55, 0.94) | 0.02 | 0.70 (0.54, 0.92) | 0.01 |
cg20595300 | 9 | UHRF2 | Cell-cycle regulation, tumorigenesis | 0.70 (0.54, 0.91) | 0.007 | 0.75 (0.58, 0.97) | 0.03 | 0.74 (0.57, 0.95) | 0.02 |
cg19048496 | 16 | TCEB2 | Transcription elongation and cellular senescence | 0.69 (0.53, 0.9) | 0.007 | 0.70 (0.53, 0.91) | 0.007 | 0.73 (0.56, 0.96) | 0.02 |
cg08728520 | 20 | COMMD7 | NF-kappa-B complex activity | 0.68 (0.51, 0.9) | 0.007 | 0.70 (0.53, 0.93) | 0.01 | 0.69 (0.51, 0.91) | 0.009 |
cg06935581 | 16 | DECR2 | Lipid metabolism | 0.68 (0.51, 0.9) | 0.007 | 0.70 (0.53, 0.93) | 0.01 | 0.70 (0.52, 0.92) | 0.01 |
cg00291981 | 3 | BSN | Spatial organization of synaptic vesicle cluster | 0.69 (0.53, 0.91) | 0.007 | 0.72 (0.55, 0.94) | 0.02 | 0.70 (0.54, 0.92) | 0.009 |
cg25944898 | 11 | PRDX5 | Cellular protection against oxidative stress | 0.69 (0.52, 0.91) | 0.008 | 0.71 (0.54, 0.93) | 0.01 | 0.71 (0.54, 0.94) | 0.02 |
cg27555392 | 1 | FBXO42 | Protein-ubiquitin ligases | 0.69 (0.53, 0.91) | 0.009 | 0.72 (0.55, 0.95) | 0.02 | 0.71 (0.54, 0.94) | 0.02 |