The emerging role of epigenetic regulation in the progression of silicosis

Clinical Epigenetics

Table 1 The main miRNA changes involved in silicosis

miRNA	Tissue/Cell/Patients	Expression level	Target gene	References
miR-449a	Mice NIH-3T3	Down	Bcl-2	[43]
miR-770-5p	MRC-5	Down	TGFBR1	[44]
miR-490-3p	MRC-5, NIH/3T3	Down	TGFBR1	[45]
miR‑29c	Rats Pulmonary fibroblasts Rat NR8383 Pulmonary macrophages	Down	TGF‑β1/α‑SMA	[46]
miR-155-5p	MEFs	Up	Mep1a	[47]
miR-7219-3p	Mice RAW264.7, HEK-293T, NIH-3T3	Up	Spouty1	[48]
miR-29b-2-5p	Mice A549, BEAS-2B	Up	MEKK2/NOTCH2	[51]
miR-34c-3p	Mice A549, BEAS-2B	Up	MEKK2/NOTCH2	[51]
let-7d	A549, THP-1	Up	HMGA2	[52]
miR-299	Rats	Up		[53]
miR-375	Rats	Down		[53]
miRNA-423-5p	Rats	Up		[54]
miRNA-26a-5p	Rats	Down		[54]
miR-146a	Rats	Up	Interleukin-1β	[55]
miR‑181b	Rats	Down	TNF-α	[55]
miR-503	Mice HBE, A549	Down	PI3K	[56]
miR-411-3p	Rats fibroblasts isolated from the lungs of newborn rats	Down	TGF-β/Smad	[57]
miR-542-5p	Mice	Down	ITGA6	[58]
miR-326	Mice HBE, A549, MRC-5, NIH/3T3	Up	TNFSF14/PTBP1	[59]
miR-489	Mice	Up	TGF-β1	[60]
miR-1224-5p	Mice NIH-3T3, MRC-5	Up	BECN1	[61]
miR-34a	Mice	Up	Smad4	[62]
miR-29b	Mice RLE-6TN	Up	COL-I/COL-III	[63]
miR-31	Mice MRC-5	Down	integrin α(5)/RhoA	[64]
miR-200	Rats MRC-5, RLE-6TN	Down	TGF-β1	[65]
miR-29	Mice	Down	TGF-β	[66]
miR-486-5p	Mice Patients	Down	Smad2/COL6A6	[67]
miR-19a	Patients	Down		[68]
miR-200c	Patients	Down		[69]
miR-29c	Patients	Down		[69]

ISSN: 1868-7083