Fig. 3

Pathway analyses of TB exposure of the alveolar macrophages and alveolar T cells. The gene count is presented as circles, increasing with elevating number of gene count. The significance level is presented as a color scale. A-B. Alveolar macrophages. Overrepresentation analysis using Panther pathways showing the top candidate pathways of the identified DMGs. The dot plot is demonstrating the most relevant pathways for the alveolar macrophages (A) and alveolar T cells (B) when comparing the controls with TB-exposed/patients. C, D Pathways for the alveolar macrophages and alveolar T cells generated with DOSE for enriched diseases (C), and KEGG pathways for enriched pathways (D). 1051 modules identified with MCODE​ and 1584 modules identified with Clique-Sum were used to identify the top 10 enriched disease and enrich pathways. TB, tuberculosis; DMGs, differentially methylated genes