Novel blood-based FUT7 DNA methylation is associated with lung cancer: especially for lung squamous cell carcinoma

Table 2 The methylation levels of FUT7_CpG_1-7 in LC, BPN and NC

Variables	LC (n = 428)	BPN (n = 233)	NC (n = 862)	Z₁ value	P₁ value	Z₂ value	P₂ value
FUT7_CpG_1	0.230 (0.168–0.300)	0.230 (0.180–0.290)	0.280 (0.220–0.320)	7.986	< 0.001***	0.458	0.647
FUT7_CpG_2	0.100 (0.080–0.130)	0.100 (0.080–0.130)	0.110 (0.090–0.140)	5.244	< 0.001***	1.926	0.055
FUT7_CpG_3	0.160 (0.100–0.210)	0.170 (0.110–0.220)	0.190 (0.150–0.240)	6.753	< 0.001***	1.587	0.113
FUT7_CpG_4	0.170 (0.130–0.200)	0.180 (0.160–0.220)	0.190 (0.160–0.220)	6.359	< 0.001***	4.035	< 0.001***
FUT7_CpG_5	0.120 (0.090–0.160)	0.120 (0.090–0.160)	0.140 (0.110–0.170)	3.227	0.001**	1.335	0.182
FUT7_CpG_6	0.110 (0.080–0.170)	0.110 (0.080–0.140)	0.130 (0.100–0.170)	2.570	0.010*	0.767	0.443
FUT7_CpG_7	0.100 (0.060–0.150)	0.120 (0.080–0.160)	0.130 (0.100–0.170)	8.167	< 0.001***	2.387	0.017*

LC lung cancer, BPN benign pulmonary nodule, NC normal control
Z₁, P₁: comparison between LC and NC using Mann–Whitney-U test; Z₂, P₂: comparison between LC and BPN using Mann–Whitney-U test
*P < 0.05; **P < 0.01; *** P < 0.001

ISSN: 1868-7083