Epigenetic silencing of JAM3 promotes esophageal cancer development by activating Wnt signaling

Clinical Epigenetics

Table 1 The association of JAM3 methylation and clinical factors in human EC

Clinical parameter	No	Methylation status		p value
	No	Methylated	Unmethylated
	760	n = 388 (51.1%)	n = 372 (48.9%)
Gender
Male	528	272	256	0.7004
Female	232	116	116
Age
< 60	196	109	87	0.1382
≥ 60	564	279	285
Tumor size
< 4 cm	247	132	115	0.3607
≥ 4 cm	513	256	257
Differentiation
Moderately/Well	583	285	298	0.0300*
Poorly	177	103	74
TNM stage
I/II	383	198	185	0.7202
III/IV	377	190	187
Lymph node metastasis
Negative	367	187	180	0.9579
Positive	393	201	192
Smoking
No	422	221	201	0.4170
Yes	338	167	171
Drinking
No	547	284	263
Yes	213	104	109	0.4436
Family history
No	524	255	269	0.0497*
Yes	236	133	103

ISSN: 1868-7083