Table 1 LINE-1 methylation in 163 patients with stage III-IV oropharyngeal squamous cell carcinoma according to sociodemographic and clinical characteristics

Sex

 Man

117

(71.8)

53.7 (38.5–72.7)

p = 0.8192

 Woman

46

(28.2)

55.8 (38.1–70.6)

Age (years)

 < 60

40

(24.5)

59.6 (38.6–75.3)

p = 0.0249

 60–69

57

(35.0)

61.3 (42.2–73.0)

 ≥ 70

66

(40.5)

47.8 (24.1–59.3)

T stage^a

 T1

24

(14.7)

70.0 (44.8–77.8)

p = 0.1137

 T2

51

(31.3)

61.8 (41.0–75.5)

 T3

57

(35.0)

51.0 (30.2–65.0)

 T4

31

(19.0)

53.4 (38.6–75.3)

N stage^a

 N0

17

(10.4)

51.0 (20.0–66.2)

p = 0.2205

 N1

28

(17.2)

50.0 (34.2–74.4)

 N2

105

(64.4)

59.7 (41.9–73.0)

 N3

13

(8.0)

52.2 (30.3–69.5)

Stage^a

 III

38

(23.3)

48.9 (27.1–70.1)

p = 0.1475

 IV

125

(76.7)

58.2 (41.0–72.7)

HPV-status

 Negative

110

(67.5)

50.1 (30.3–66.2)

p < 0.0001^b

 Positive

46

(28.2)

71.2 (58.6–78.2)

 Unknown

7

(4.3)

46.1 (29.5–51.1)

Surgery

 No

73

(44.8)

58.6 (42.1–77.2)

p = 0.1144

 Yes

90

(55.2)

52.5 (37.9–70.1)