Fig. 4

Comparison of birthweight epigenome-wide association analysis results with or without controlling for mQTL (EPIC array). Similar to that of Fig. 3, two EWAS models (mQTL-model and non-mQTL-model) were run. Regression effect sizes and P values of 155,852 CpGs were compared. A Regression β coefficients from these two models were compared for CpGs on the EPIC array. The 3354 CpGs that were significant were marked red, and CpGs that were not significant were marked turquoise. Red lines represent x = 0, y = 0 and x = y, respectively. B Negative log P values from these two models were compared, with significant CpGs marked red. X = y is shown with a red line