From: Methylation of the serotonin reuptake transporter gene and non-motor symptoms in dystonia patients
 | CD (n = 49) | M-D (n = 41) | DRD (n = 27) | Controls (n = 56) | p-value1 | Dystonia (n = 117) | p value2 |
---|---|---|---|---|---|---|---|
Age (SD) | 54 (11) | 44 (20) | 37 (22) | 50 (17) | 0.00a | 47 (19) | 0.27b |
Gender M | 14 (29%) | 17 (42%) | 9 (33%) | 16 (29%) | 0.52c | 40 (34%) | 0.46c |
Genotype | Â | Â | Â | Â | Â | Â | Â |
LA/LA | 7 (14%) | 12 (29%) | 12 (44%) | 14 (25%) | 0.03c | 31 (27%) | 0.79c |
S/S | 11 (22%) | 4 (10%) | 5 (19%) | 10 (18%) | 0.58c | 20 (17%) | 0.94c |
LA/S | 25 (51%) | 13 (32%) | 7 (26%) | 21 (38%) | 0.16c | 45 (39%) | 0.84c |
LA/LG | 5 (10%) | 4 (10%) | 2 (7%) | 6 (11%) | 0.96c | 11 (9%) | 0.81c |
S/LG | 1 (2%) | 3 (7%) | 1 (4%) | 4 (7%) | 0.54c | 5 (4%) | 0.44c |
LG/LG | 0 | 1 (2%) | 0 | 0 | 0.31c | 1 (1%) | 0.48c |
CGI (range) | 4 (2–7) | 3 (1–5) | 2 (1–3) |  | 0.00d |  |  |
Duration dystonia in years (range) | 10 (1–52) | 47 (7–73) | 23 (1–71) |  | 0.00d |  |  |
BDI (range)* | 8 (0–28) | 8 (0–30) | 5 (0–18) | 3 (0–19) | 0.00d | 8 (0–30) | 0.00e |
BAI (range)* | 8 (1–31) | 8 (0–42) | 6 (0–12) | 3 (0–21) | 0.00d | 7 (0–42) | 0.00e |
CDI (range)** | NA | 101 (82–126) | 88 (73–117) | 98 (84–103) | 0.28d | 89 (73–126) | 0.75e |
SCARED (range)** | NA | 4 (1–12) | 6 (2–19) | 2 (1–24) | 0.40d | 4 (1–19) | 0.27e |
(C)Y-BOCS (range) | 0 (0–12) | 0 (0–12) | 0 (0–18) | 0 (0–9) | 0.10d | 0 (0–18) | 0.03e |
Psychiatric diagnosis | 33 (67%) | 24 (59%) | 17 (63%) | 17 (30%) | 0.00c | 74 (63%) | 0.00c |
Depressive disorder | 16 (33%) | 13 (32%) | 9 (33%) | 8 (14%) | 0.09c | 38 (33%) | 0.01c |
Anxiety disorder | 22 (45%) | 20 (49%) | 12 (44%) | 5 (9%) | 0.00c | 54 (46%) | 0.00c |