Pathway | Percentage mediated | Total effect (TE) | Natural direct effect (NDE) | Natural indirect effect (NIE) | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AA | Mediator | Estimate | 95%CI | P | Estimate | 95%CI | P | Estimate | 95%CI | P | Estimate | 95%CI | P | ||||
Biomarker | Lower | Upper | Lower | Upper | Lower | Upper | Lower | Upper | |||||||||
HAA | HDL |  − 0.049 |  − 8.922 | 9.164 | 0.987 | 0.012 | 0.005 | 0.019 | 0.001 | 0.012 | 0.005 | 0.019 | 0.001 |  − 0.000006 |  − 0.0009 | 0.0009 | 0.987 |
HAA | Trigly |  − 1.392 |  − 14.450 | 2.048 | 0.542 | 0.012 | 0.005 | 0.019 | 0.001 | 0.012 | 0.005 | 0.019 | 0.001 |  − 0.00017 |  − 0.0013 | 0.0002 | 0.530 |
HAA | DBP |  − 0.615 |  − 14.124 | 2.134 | 0.666 | 0.009 | 0.003 | 0.015 | 0.006 | 0.009 | 0.003 | 0.015 | 0.005 |  − 0.00005 |  − 0.0008 | 0.0002 | 0.661 |
HAA | BMI |  − 0.724 |  − 16.968 | 2.089 | 0.635 | 0.009 | 0.003 | 0.015 | 0.006 | 0.009 | 0.003 | 0.015 | 0.005 |  − 0.00006 |  − 0.0008 | 0.0002 | 0.629 |
HAA | NUMDZV | 0.769 |  − 3.483 | 12.295 | 0.711 | 0.010 | 0.004 | 0.016 | 0.003 | 0.009 | 0.004 | 0.016 | 0.003 | 0.00007 |  − 0.0003 | 0.0009 | 0.711 |
HAA | CAD |  − 2.093 |  − 19.996 | 4.708 | 0.577 | 0.009 | 0.003 | 0.015 | 0.004 | 0.009 | 0.003 | 0.016 | 0.003 |  − 0.0002 |  − 0.001 | 0.0004 | 0.562 |
PhenoAA | ANG2 | 19.781 | 6.688 | 48.483 | 0.016 | 0.010 | 0.005 | 0.016 |  < .0001 | 0.008 | 0.003 | 0.014 | 0.002 | 0.002 | 0.0008 | 0.0038 | 0.004 |
PhenoAA | HDL | 0.028 |  − 4.515 | 5.645 | 0.986 | 0.013 | 0.007 | 0.019 |  < .0001 | 0.013 | 0.007 | 0.019 |  < .0001 | 0.000004 |  − 0.0005 | 0.0007 | 0.986 |
PhenoAA | BMI |  − 0.432 |  − 7.229 | 1.098 | 0.638 | 0.011 | 0.006 | 0.016 |  < .0001 | 0.011 | 0.006 | 0.016 |  < .0001 |  − 0.00005 |  − 0.0007 | 0.0001 | 0.636 |
PhenoAA | NUMDZV | 0.067 |  − 3.467 | 5.138 | 0.961 | 0.011 | 0.006 | 0.016 |  < .0001 | 0.011 | 0.006 | 0.016 |  < .0001 | 0.000008 |  − 0.0004 | 0.0005 | 0.961 |
PhenoAA | LVEF | 6.089 | 0.924 | 17.785 | 0.093 | 0.011 | 0.006 | 0.016 |  < .0001 | 0.011 | 0.006 | 0.015 |  < .0002 | 0.0007 | 0.000 | 0.002 | 0.084 |
PhenoAA | CAD |  − 0.620 |  − 7.942 | 3.785 | 0.785 | 0.011 | 0.006 | 0.016 |  < .0001 | 0.011 | 0.006 | 0.016 |  < .0001 |  − 0.0001 |  − 0.001 | 0.0004 | 0.783 |
PhenoAA | Diabetes | 8.153 | 1.520 | 22.822 | 0.043 | 0.012 | 0.007 | 0.017 |  < .0001 | 0.011 | 0.006 | 0.016 |  < .0001 | 0.0010 | 0.000 | 0.002 | 0.034 |
GrimAA | ANG2 | 12.264 | 3.402 | 26.933 | 0.014 | 0.022 | 0.015 | 0.029 |  < .0001 | 0.011 | 0.012 | 0.026 |  < .0001 | 0.0027 | 0.0008 | 0.0054 | 0.009 |
GrimAA | HDL |  − 0.659 |  − 7.671 | 4.096 | 0.762 | 0.023 | 0.015 | 0.031 |  < .0001 | 0.023 | 0.015 | 0.031 |  < .0001 |  − 0.00015 |  − 0.0016 | 0.0009 | 0.762 |
GrimAA | SBP | 0.074 |  − 1.795 | 3.218 | 0.920 | 0.021 | 0.014 | 0.029 |  < .0001 | 0.021 | 0.014 | 0.029 |  < .0001 | 0.000016 |  − 0.0004 | 0.0006 | 0.920 |
GrimAA | BMI |  − 0.115 |  − 3.388 | 1.175 | 0.812 | 0.021 | 0.014 | 0.028 |  < .0001 | 0.021 | 0.014 | 0.028 |  < .0001 |  − 0.00002 |  − 0.0007 | 0.0002 | 0.812 |
GrimAA | NUMDZV | 1.166 |  − 0.535 | 7.502 | 0.379 | 0.022 | 0.015 | 0.029 |  < .0001 | 0.022 | 0.014 | 0.029 |  < .0001 | 0.00026 |  − 0.0001 | 0.0014 | 0.376 |
GrimAA | LVEF | 5.277 | 0.812 | 15.613 | 0.065 | 0.022 | 0.015 | 0.029 |  < .0001 | 0.021 | 0.013 | 0.028 |  < .0001 | 0.0012 | 0.0002 | 0.0031 | 0.057 |
GrimAA | CAD | 2.952 |  − 0.045 | 11.140 | 0.164 | 0.022 | 0.015 | 0.029 |  < .0001 | 0.021 | 0.014 | 0.029 |  < .0001 | 0.001 |  − 0.00001 | 0.002 | 0.157 |