The association of accelerated epigenetic age with all-cause mortality in cardiac catheterization patients as mediated by vascular and cardiometabolic outcomes

Table 5 Summary of percentage mediated, total effect, direct effect, and indirect effect of AAs to mortality through mediators for those mediation analyses with significant (P < 0.05) mediation

Pathway	AA biomarker	PhenoAA	PhenoAA	GrimAA	GrimAA*
Pathway	Mediator	ANG2	Diabetes	ANG2	LVEF*
Percentage mediated	Estimate	19.8	8.15	12.3	5.277
	95% Lower	6.69	1.52	3.4	0.812
	95% Upper	48.483	22.822	26.933	15.613
	P	0.016	0.043	0.014	0.065
Total effect (TE)	Estimate	0.01	0.012	0.022	0.022
	95% Lower	0.005	0.007	0.015	0.015
	95% Upper	0.016	0.017	0.029	0.029
	P	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Natural direct effect (NDE)	Estimate	0.008	0.011	0.019	0.021
	95% Lower	0.003	0.006	0.012	0.013
	95% Upper	0.014	0.016	0.026	0.028
	P	0.002	< 0.0001	< 0.0001	< 0.0001
Natural indirect effect (NIE)	Estimate	0.002	0.001	0.0027	0.0012
	95% Lower	0.0008	0	0.0008	0.0002
	95% Upper	0.0038	0.002	0.0054	0.0031
	P	0.004	0.034	0.009	0.057

The complete results from the mediation analysis are given in Table 6
*The mediation analysis for GrimAA to LVEF to mortality was marginally significant (indirect effect P = 0.057)

ISSN: 1868-7083