The association of accelerated epigenetic age with all-cause mortality in cardiac catheterization patients as mediated by vascular and cardiometabolic outcomes

Table 4 P values of the association between AAs and potential mediators using univariate regression models

	HAA	PhenoAA	GrimAA
Angiopoietin-2	0.65	< 0.0001 +	0.0001 +
HDL cholesterol	< 0.0001 −	0.001 −	< 0.0001 −
LDL cholesterol	0.95	0.97	0.29
Total cholesterol	0.34	0.76	0.97
Triglyceride	0.04 +	0.14	0.23
Systolic blood pressure	0.15	0.06	0.002 −
Diastolic blood pressure	0.007 +	0.37	0.10
Body mass index	0.0003 +	0.001 +	0.0004 +
Number of disease vessels	0.0007 −	0.02 −	0.003 −
Left ventricular ejection fraction	0.98	0.05	0.008 −
Peripheral artery disease	0.38	0.41	0.19
Coronary artery disease	< 0.0001 −	0.009 −	0.03 −
Congestive heart failure	0.10	0.41	0.78
Diabetes	0.10	0.002 +	0.16

Bold indicates nominally significant at P < 0.05; + indicates a positive univariate association; − indicates a negative univariate association

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