Table 1 Liver tissue samples in the initial and validation cohorts
Cohorts | Samples | Number of specimens | Histological findings in non-cancerous liver tissue (N) | Coexistence of hepatocellular carcinoma (HCC) | Hepatitis virus infection |
|---|---|---|---|---|---|
Initial cohort | Normal liver tissue (NLT) from patients with liver metastasis of colorectal cancer (CRC) | 36 | Normal | No | No |
N showing non-alcoholic steatohepatitis (NASH) from patients with morbid obesity without HCC (NASH-O) | 91 | NASH | No | No | |
N showing NASH from patients with HCC (NASH-W) | 22 | NASH | Yes | No | |
HCC (T) | 22 | NASH | N/A | No | |
Validation cohort | NLT from patients with liver metastasis of CRC | 22 | Normal | No | No |
N showing non-alcoholic fatty liver (NAFL), but not satisfying the criteria for NASH, from patients with liver metastasis of CRC (NAFL-O) | 9 | NAFL | No | No | |
N showing NASH from patients with liver metastasis of CRC (NASH-O) | 3 | NASH | No | No | |
N showing NAFL from patients with HCC (NAFL-W) | 10 | NAFL | Yes | No | |
NASH-W | 11 | NASH | Yes | No |